CHEM 3341: Laboratory for Organic Chemistry II
This lab course is for biochemistry and non-chemistry majors. Chem 3341 is a continuation of Chem 3321, Organic Chemistry I Lab. The laboratory techniques learned in 3321 are used to carry out reactions in aromatic substitution, organometallic chemistry, oxidation and reduction chemistry, esterifications, aldol condensations, and Wittig chemistry. A significant portion of the semester is devoted to separating and determining the structure of unknown organic compounds, as well as verifying the identification of compounds synthesized in lab.
- 3321 Course Syllabus, Schedule and Policies
- Drawer check-in sheet and glassware prices
- Example lab report
TA office hours and emails are posted here.
| Lab | Day | Time | Location | TA |
| 201 | T | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 211 | T | 1:50 PM-4:40 PM | EKLC M1B25 | |
| 221 | W | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 222 | W | 10:20 AM-1:10 PM | EKLC M1B35 | |
| 231 | W | 1:50 PM-4:40 PM | EKLC M1B25 | |
| 232 | W | 1:50 PM-4:40 PM | EKLC M1B35 | |
| 241 | W | 5:30 PM-8:20 PM | EKLC M1B25 | |
| 242 | W | 5:30 PM-8:20 PM | EKLC M1B35 | |
| 251 | R | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 261 | R | 1:50 PM-4:40 PM | EKLC M1B25 | |
| 271 | R | 5:30 PM-8:20 PM | EKLC M1B25 | |
| 272 | R | 5:30 PM-8:20 PM | EKLC M1B35 | |
| 281 | F | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 282 | F | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 291 | F | 1:50 PM-4:40 PM | EKLC M1B25 | |
| 292 | F | 1:50 PM-4:40 PM | EKLC M1B35 | |
| 294 | M | 10:20 AM-1:10 PM | EKLC M1B25 | |
| 295 | M | 10:20 AM-1:10 PM | EKLC M1B35 | |
| 296 | M | 1:50 PM-4:40 PM | remote | |
| 297 | M | 1:50 PM-4:40 PM | remote | |
| 298 | M | 5:30 PM-8:20 PM | remote | |
| 299 | M | 5:30 PM-8:20 PM | remote |
Experiment Schedule
| Dates | Experiment | Quiz | Notes |
| Mon Aug 24 - Fri Aug 28 | Lab check-in & NMR Review | No | If you don't remember NMR from OChem 1, read up on it ahead of time. These sources are helpful: Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site. The in-class Spectroscopy Worksheet, the Spectroscopy Homework, and the Practical NMR lab are not due as part of this lab, but they may be helpful. |
| Mon Aug 31 - Fri Sep 4 | Exp. 14: Epoxidation of Cholesterol | Yes (SQ Answers) | This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab! Lab Safety (for review!) |
| Mon Sep 7 - Fri Sep 11 | Exp. 15: Diels-Alder Reaction | Yes (SQ Answers) | NMR spectrum of the adduct. You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants. Since Sep. 7 is Labor Day, students in Monday labs will have to perform this experiment remotely. |
| Mon Sep 14 - Fri Sep 18 | Exp. 16: Electrophilic Aromatic Substitution | Yes (SQ Answers) | |
| Mon Sep 21 - Fri Sep 25 | Exp. 17: Microscale Column Chromatography | Yes (SQ Answers) | See the section on how to run a flash column in the
Column Chromatography Section. |
| Mon Sep 28 - Fri Oct 2 | Exp. 18: Identification of Unknowns, day 1 | Yes (SQ Answers) | Identification of Unknowns rubric
A visual guide to this lab NMR spectra for all compounds |
| Mon Oct 5 - Fri Oct 9 | Exp. 18: Identification of Unknowns, day 2 | No | The ID of Unknowns paper is due three lab periods from now. |
| Mon Oct 12 - Fri Oct 16 | Exp. 19: Reduction of Ketones | Yes (SQ Answers) | |
| Mon Oct 19 - Fri Oct 23 | Exp. 20: Wittig Reaction | Yes (SQ Answers) | You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants. |
| Mon Oct 26 - Fri Oct 30 | Exp. 21: Grignard Dyes | Yes (SQ Answers) | The ID of Unknowns paper is due. You will need the Handbook supplement on UV-Visible and Fluorescence Spectroscopy. |
| Mon Nov 2 - Fri Nov 6 | Exp. 22: Liquid Crystals | Yes (SQ Answers) | |
| Mon Nov 9 - Fri Nov 13 | Exp. 23: Fischer Esterification | Yes (SQ Answers) | NMR spectra of all 5 esters. Note that these are for the methyl esters, not the ethyl esters, so you will have to keep this in mind when comparing your own spectra. |
| Mon Nov 16 - Fri Nov 20 | Exp. 24: Aldol Condensation & Lab Check-out | Yes (SQ Answers) | You will need the Handbook supplements on Green Chemistry and UV-Visible and Fluorescence Spectroscopy. |
| Tue Apr 21 - Fri Apr 24 | Final Quiz | Yes | For the final quiz, you should review the study questions and prelab quizzes. |