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CHEM 3341: Laboratory for Organic Chemistry II

This lab course is for biochemistry and non-chemistry majors. Chem 3341 is a continuation of Chem 3321, Organic Chemistry I Lab. The laboratory techniques learned in 3321 are used to carry out reactions in aromatic substitution, organometallic chemistry, oxidation and reduction chemistry, esterifications, aldol condensations, and Wittig chemistry. A significant portion of the semester is devoted to separating and determining the structure of unknown organic compounds, as well as verifying the identification of compounds synthesized in lab.

TA office hours and emails are posted here.

LabDayTimeLocationTATA Email
215M1:50 PM-4:40 PMEKLC M1B25Shea O'SullivanShea.Osullivan@colorado.edu
216M1:50 PM-4:40 PMEKLC M1B35Shea O'SullivanShea.Osullivan@colorado.edu
221T10:20 AM-1:10 PMEKLC M1B20Brandon BishopBrandon.Bishop@colorado.edu
222T10:20 AM-1:10 PMEKLC M1B25Claire BoronskiClaire.Boronski@colorado.edu
223T10:20 AM-1:10 PMEKLC M1B35Claire BoronskiClaire.Boronski@colorado.edu
224T1:50 PM-4:40 PMEKLC M1B20Lacey WaymentLacey.Wayment@colorado.edu
225T1:50 PM-4:40 PMEKLC M1B25Brandon BishopBrandon.Bishop@colorado.edu
226T1:50 PM-4:40 PMEKLC M1B35Brandon BishopBrandon.Bishop@colorado.edu
231W10:20 AM-1:10 PMEKLC M1B20Lacey WaymentLacey.Wayment@colorado.edu
232W10:20 AM-1:10 PMEKLC M1B25Hongxuan ChenHongxuan.Chen@colorado.edu
233W10:20 AM-1:10 PMEKLC M1B35Hongxuan ChenHongxuan.Chen@colorado.edu
234W1:50 PM-4:40 PMEKLC M1B20Lacey WaymentLacey.Wayment@colorado.edu
235W1:50 PM-4:40 PMEKLC M1B25Keira CulleyKeira.Culley@colorado.edu
236W1:50 PM-4:40 PMEKLC M1B35Keira CulleyKeira.Culley@colorado.edu
237W5:30 PM-8:20 PMremoteRuiheng JingRuiheng.Jing@colorado.edu
238W5:30 PM-8:20 PMremoteShaofeng HuangShaofeng.Huang@colorado.edu
239W5:30 PM-8:20 PMremoteHongxuan ChenHongxuan.Chen@colorado.edu
242R10:20 AM-1:10 PMEKLC M1B25Claire BoronskiClaire.Boronski@colorado.edu
243R10:20 AM-1:10 PMEKLC M1B35Claire BoronskiClaire.Boronski@colorado.edu
244R1:50 PM-4:40 PMEKLC M1B20Keira CulleyKeira.Culley@colorado.edu
245R1:50 PM-4:40 PMEKLC M1B25Shea O'SullivanShea.Osullivan@colorado.edu
246R1:50 PM-4:40 PMEKLC M1B35Shea O'SullivanShea.Osullivan@colorado.edu
247R5:30 PM-8:20 PMremoteZepeng LeiZepeng.Lei@colorado.edu
248R5:30 PM-8:20 PMremoteRuiheng JingRuiheng.Jing@colorado.edu
249R5:30 PM-8:20 PMremoteBrandon BishopBrandon.Bishop@colorado.edu
251F10:20 AM-1:10 PMremoteZepeng LeiZepeng.Lei@colorado.edu
254F1:50 PM-4:40 PMremoteZepeng LeiZepeng.Lei@colorado.edu
255F1:50 PM-4:40 PMremoteScott BrodyScott.Brody@colorado.edu

Experiment Schedule

To find which experiment you will perform each week, look up your section and the week in the first table below, then check this number against the second table below. “n/a” means your lab section will not meet during that week.

Mon Jan 11 - Fri Jan 15n/an/an/an/an/a
Mon Jan 18 - Fri Jan 22n/an/a000
Mon Jan 25 - Fri Jan 2900141414
Mon Feb 1 - Fri Feb 51414151515
Mon Feb 8 - Fri Feb 121515161616
Mon Feb 15 - Fri Feb 191616n/a1717
Mon Feb 22 - Fri Feb 2617171718.118.1
Mon Mar 1 - Fri Mar 518.
Mon Mar 8 - Fri Mar 1218.218.218.21919
Mon Mar 15 - Fri Mar 191919192020
Mon Mar 22 - Fri Mar 26202020n/a21
Mon Mar 29 - Fri Apr 22121212122
Mon Apr 5 - Fri Apr 92222222223
Mon Apr 12 - Fri Apr 162323232324
Mon Apr 19 - Fri Apr 2324242424F
Mon Apr 26 - Fri Apr 30FFFFn/a

Experiment Schedule

# Experiment Quiz Notes
Syllabus, COVID safety & NMR review
No If you don't remember NMR from OChem 1, read up on it ahead of time. These sources are helpful:
Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet, the Spectroscopy Homework, and the Practical NMR lab are not due as part of this lab, but they may be helpful.
Drawer check-in & Epoxidation of Cholesterol
Yes (SQ Answers) This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab!
Lab Safety (for review!)
Diels-Alder Reaction
Yes (SQ Answers) During the week of Labor Day, all Monday students will have to perform this experiment remotely.
NMR spectrum of the adduct. You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants.
Since Sep. 7 is Labor Day, students in Monday labs will have to perform this experiment remotely.
Electrophilic Aromatic Substitution
Yes (SQ Answers)
Microscale Column Chromatography
Yes (SQ Answers) See the section on how to run a flash column in the Column Chromatography Section.
Identification of Unknowns, day 1
Yes (SQ Answers) Identification of Unknowns rubric
A visual guide to this lab
NMR spectra for all compounds
Identification of Unknowns, day 2
No The ID of Unknowns paper is due four lab periods from now.
Reduction of Ketones
Yes (SQ Answers)
Wittig Reaction
Yes (SQ Answers) You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants.
Grignard Dyes
Yes (SQ Answers)
Liquid Crystals
Yes (SQ Answers) The ID of Unknowns paper is due.
Fischer Esterification
Yes (SQ Answers) NMR spectra of all 5 esters. Note that these are for the methyl esters, not the ethyl esters, so you will have to keep this in mind when comparing your own spectra.
Aldol Condensation & Lab Check-out
Yes (SQ Answers)
Final Quiz
Yes For the final quiz, you should review the study questions and prelab quizzes.