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CHEM 3341: Laboratory for Organic Chemistry II

This lab course is for biochemistry and non-chemistry majors. Chem 3341 is a continuation of Chem 3321, Organic Chemistry I Lab. The laboratory techniques learned in 3321 are used to carry out reactions in aromatic substitution, organometallic chemistry, oxidation and reduction chemistry, esterifications, aldol condensations, and Wittig chemistry. A significant portion of the semester is devoted to separating and determining the structure of unknown organic compounds, as well as verifying the identification of compounds synthesized in lab.

TA office hours and emails are posted here.

201T10:20 AM-1:10 PMEKLC M1B25 
211T1:50 PM-4:40 PMEKLC M1B25 
221W10:20 AM-1:10 PMEKLC M1B25 
222W10:20 AM-1:10 PMEKLC M1B35 
231W1:50 PM-4:40 PMEKLC M1B25 
232W1:50 PM-4:40 PMEKLC M1B35 
241W5:30 PM-8:20 PMEKLC M1B25 
242W5:30 PM-8:20 PMEKLC M1B35 
251R10:20 AM-1:10 PMEKLC M1B25 
261R1:50 PM-4:40 PMEKLC M1B25 
271R5:30 PM-8:20 PMEKLC M1B25 
272R5:30 PM-8:20 PMEKLC M1B35 
281F10:20 AM-1:10 PMEKLC M1B25 
282F10:20 AM-1:10 PMEKLC M1B25 
291F1:50 PM-4:40 PMEKLC M1B25 
292F1:50 PM-4:40 PMEKLC M1B35 
294M10:20 AM-1:10 PMEKLC M1B25 
295M10:20 AM-1:10 PMEKLC M1B35 
296M1:50 PM-4:40 PMremote 
297M1:50 PM-4:40 PMremote 
298M5:30 PM-8:20 PMremote 
299M5:30 PM-8:20 PMremote

Experiment Schedule

Dates Experiment Quiz Notes
Mon Aug 24 - Fri Aug 28 Lab check-in & NMR Review No If you don't remember NMR from OChem 1, read up on it ahead of time. These sources are helpful:
Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet, the Spectroscopy Homework, and the Practical NMR lab are not due as part of this lab, but they may be helpful.
Mon Aug 31 - Fri Sep 4 Exp. 14: Epoxidation of Cholesterol Yes (SQ Answers) This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab!
Lab Safety (for review!)
Mon Sep 7 - Fri Sep 11 Exp. 15: Diels-Alder Reaction Yes (SQ Answers) NMR spectrum of the adduct. You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants.
Since Sep. 7 is Labor Day, students in Monday labs will have to perform this experiment remotely.
Mon Sep 14 - Fri Sep 18 Exp. 16: Electrophilic Aromatic Substitution Yes (SQ Answers)
Mon Sep 21 - Fri Sep 25 Exp. 17: Microscale Column Chromatography Yes (SQ Answers) See the section on how to run a flash column in the Column Chromatography Section.
Mon Sep 28 - Fri Oct 2 Exp. 18: Identification of Unknowns, day 1 Yes (SQ Answers) Identification of Unknowns rubric
A visual guide to this lab
NMR spectra for all compounds
Mon Oct 5 - Fri Oct 9 Exp. 18: Identification of Unknowns, day 2 No The ID of Unknowns paper is due three lab periods from now.
Mon Oct 12 - Fri Oct 16 Exp. 19: Reduction of Ketones Yes (SQ Answers)
Mon Oct 19 - Fri Oct 23 Exp. 20: Wittig Reaction Yes (SQ Answers) You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants.
Mon Oct 26 - Fri Oct 30 Exp. 21: Grignard Dyes Yes (SQ Answers) The ID of Unknowns paper is due. You will need the Handbook supplement on UV-Visible and Fluorescence Spectroscopy.
Mon Nov 2 - Fri Nov 6 Exp. 22: Liquid Crystals Yes (SQ Answers)
Mon Nov 9 - Fri Nov 13 Exp. 23: Fischer Esterification Yes (SQ Answers) NMR spectra of all 5 esters. Note that these are for the methyl esters, not the ethyl esters, so you will have to keep this in mind when comparing your own spectra.
Mon Nov 16 - Fri Nov 20 Exp. 24: Aldol Condensation & Lab Check-out Yes (SQ Answers) You will need the Handbook supplements on Green Chemistry and UV-Visible and Fluorescence Spectroscopy.
Tue Apr 21 - Fri Apr 24 Final Quiz Yes For the final quiz, you should review the study questions and prelab quizzes.