CHEM 3341: Laboratory for Organic Chemistry II
This lab course is for biochemistry and non-chemistry majors. Chem 3341 is a continuation of Chem 3321, Organic Chemistry I Lab. The laboratory techniques learned in 3321 are used to carry out reactions in aromatic substitution, organometallic chemistry, oxidation and reduction chemistry, esterifications, aldol condensations, and Wittig chemistry. A significant portion of the semester is devoted to separating and determining the structure of unknown organic compounds, as well as verifying the identification of compounds synthesized in lab.
- 3341 Course Syllabus, Schedule and Policies
- Traffic flow patterns for Ekeley M1B floor
- Drawer check-in sheet and glassware prices
- Example lab report
TA office hours and emails are posted here.
| Lab | Day | Time | Location | TA |
| 201 | T | 10:20 AM-1:10 PM | EKLC M1B25 | Lacey Wayment |
| 211 | T | 1:50 PM-4:40 PM | EKLC M1B25 | Shaofeng Huang |
| 221 | W | 10:20 AM-1:10 PM | EKLC M1B25 | Hongxuan Chen |
| 222 | W | 10:20 AM-1:10 PM | EKLC M1B35 | Hongxuan Chen |
| 231 | W | 1:50 PM-4:40 PM | EKLC M1B25 | Hongxuan Chen |
| 232 | W | 1:50 PM-4:40 PM | EKLC M1B35 | Hongxuan Chen |
| 241 | W | 5:30 PM-8:20 PM | EKLC M1B25 | Hongxuan Chen |
| 242 | W | 5:30 PM-8:20 PM | EKLC M1B35 | Hongxuan Chen |
| 251 | R | 10:20 AM-1:10 PM | EKLC M1B25 | Shea OSullivan |
| 261 | R | 1:50 PM-4:40 PM | EKLC M1B25 | Shaofeng Huang |
| 271 | R | 5:30 PM-8:20 PM | EKLC M1B25 | Shea OSullivan |
| 272 | R | 5:30 PM-8:20 PM | EKLC M1B35 | Shea OSullivan |
| 281 | F | 10:20 AM-1:10 PM | EKLC M1B25 | Zepeng Lei |
| 282 | F | 10:20 AM-1:10 PM | EKLC M1B25 | Zepeng Lei |
| 291 | F | 1:50 PM-4:40 PM | EKLC M1B25 | Wyatt Powell |
| 292 | F | 1:50 PM-4:40 PM | EKLC M1B35 | Wyatt Powell |
| 295 | M | 10:20 AM-1:10 PM | EKLC M1B35 | Lacey Wayment |
| 296 | M | 1:50 PM-4:40 PM | remote | Lacey Wayment |
| 297 | M | 1:50 PM-4:40 PM | remote | Lacey Wayment |
| 298 | M | 5:30 PM-8:20 PM | remote | Brianna Callahan |
| 299 | M | 5:30 PM-8:20 PM | remote | Brianna Callahan |
Experiment Schedule
| Dates | Experiment | Quiz | Notes |
| Mon Aug 24 - Fri Aug 28 | REMOTE Syllabus, COVID safety & NMR review |
No | If you don't remember NMR from OChem 1, read up on it ahead of time. These sources are helpful: Chapters 18 & 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site. The in-class Spectroscopy Worksheet, the Spectroscopy Homework, and the Practical NMR lab are not due as part of this lab, but they may be helpful. |
| Mon Aug 31 - Fri Sep 4 | Drawer check-in & Exp. 14: Epoxidation of Cholesterol | Yes (SQ Answers) | This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab! Lab Safety (for review!) |
| Mon Sep 7 - Fri Sep 11 | Exp. 15: Diels-Alder Reaction | Yes (SQ Answers) | During the week of Labor Day, all Monday students will have to perform this experiment remotely. NMR spectrum of the adduct. You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants. Since Sep. 7 is Labor Day, students in Monday labs will have to perform this experiment remotely. |
| Mon Sep 14 - Fri Sep 18 | Exp. 16: Electrophilic Aromatic Substitution | Yes (SQ Answers) | |
| Mon Sep 21 - Fri Sep 25 | Exp. 17: Microscale Column Chromatography | Yes (SQ Answers) | See the section on how to run a flash column in the
Column Chromatography Section. |
| Mon Sep 28 - Fri Oct 2 | Exp. 18: Identification of Unknowns, day 1 | Yes (SQ Answers) | Identification of Unknowns rubric
A visual guide to this lab NMR spectra for all compounds |
| Mon Oct 5 - Fri Oct 9 | Exp. 18: Identification of Unknowns, day 2 | No | The ID of Unknowns paper is due three lab periods from now. |
| Mon Oct 12 - Fri Oct 16 | Exp. 19: Reduction of Ketones | Yes (SQ Answers) | |
| Mon Oct 19 - Fri Oct 23 | Exp. 20: Wittig Reaction | Yes (SQ Answers) | You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants. |
| Mon Oct 26 - Fri Oct 30 | Exp. 21: Grignard Dyes | Yes (SQ Answers) | The ID of Unknowns paper is due. You will need the Handbook supplement on UV-Visible and Fluorescence Spectroscopy. |
| Mon Nov 2 - Fri Nov 6 | Exp. 22: Liquid Crystals | Yes (SQ Answers) | |
| Mon Nov 9 - Fri Nov 13 | Exp. 23: Fischer Esterification | Yes (SQ Answers) | NMR spectra of all 5 esters. Note that these are for the methyl esters, not the ethyl esters, so you will have to keep this in mind when comparing your own spectra. |
| Mon Nov 16 - Fri Nov 20 | Exp. 24: Aldol Condensation & Lab Check-out | Yes (SQ Answers) | You will need the Handbook supplements on Green Chemistry and UV-Visible and Fluorescence Spectroscopy. |
| Mon Nov 30 - Fri Dec 4 | Final Quiz | Yes | For the final quiz, you should review the study questions and prelab quizzes. |