CHEM 3381: Majors Laboratory for Organic Chemistry II
This lab course is for chemistry majors. Biochemistry majors are encouraged, but not required, to take this course. Non-chemistry majors can also take this course if they wish. This course meets twice a week and is worth 2 credit hours.
CHEM 3381 covers some of the same material as does CHEM 3341, as well as a Wittig reaction, a Grubbs metathesis, an aromatic multi-step synthesis lab that covers three lab periods, and synthesis of frambinone that uses aldol condensation and catalytic hydrogenation. CHEM 3381 also includes two independent projects: one week of natural product isolation, and three weeks of a synthesis project.
- 3381 Course Syllabus, Schedule and Policies
- Traffic flow patterns for Ekeley M1B floor
- Drawer check-in sheet and glassware prices
- Example lab report
| Lab | Day | Time | Location | TA |
| 401 | TR | 10:20 AM-1:10 PM | EKLC M1B35 | Yiming Hu |
| 411 | TR | 1:50 PM-4:40 PM | EKLC M1B35 | Micah Ohlhausen |
Experiment Schedule
| Dates | Experiment | Bring | Quiz | Notes |
| Tue Aug 25 | REMOTE Syllabus, COVID safety & NMR review |
(nothing) | No | If you don't remember NMR from OChem 1, read up on it ahead of time. These sources are helpful: Chapter 18 & Chapter 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site. The in-class Spectroscopy Worksheet, the Spectroscopy Homework, and the Practical NMR lab are not due as part of this lab, but they may be helpful. |
| Thu Aug 27 | No labs | |||
| Tue Sep 1 | Drawer check-in & Exp. 31: Large-Scale Column Chromatography | Prelab | Yes (SQ Answers) | This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab! Lab Safety (for review!) |
| Thu Sep 3 | Exp. 32: Alkyne Formation | Prelab | Yes (SQ Answers) | |
| Tue Sep 8 | Exp. 33: Halogenation of Alkanes | Prelab | Yes (SQ Answers) | |
| Thu Sep 10 | Exp. 34: Substitution Kinetics | Prelab | Yes (SQ Answers) | You will need the calculations spreadsheet for this lab. |
| Tue Sep 15 | Exp. 35: Oxidation of a Diol | Prelab | Yes (SQ Answers) | |
| Thu Sep 17 | Exp. 14: Epoxidation of Cholesterol | Prelab | Yes (SQ Answers) | During this experiment, you will prepare the reaction for Grubbs Metathesis. |
| Tue Sep 22 | Exp. 36: Grubbs Metathesis | Prelab | Yes (SQ Answers) | |
| Thu Sep 24 | Exp. 37: Palladium Coupling | Prelab | Yes (SQ Answers) | During this experiment, you will also start selecting your project for the Multistep Synthesis Project (Exp. 42). Read this experiment in advance and bring a laptop if you have one. |
| Tue Sep 29 | Exp. 15: Diels-Alder Reaction | Prelab | Yes (SQ Answers) | NMR spectrum of the adduct. You will need the Handbook supplements on Green Chemistry and NMR Coupling Constants. |
| Thu Oct 1 | Exp. 38: Aromatic Multistep Synthesis, day 1 | Prelab | Yes (SQ Answers) | Details will be posted here later in the semester. |
| Tue Oct 6 | Exp. 38: Aromatic Multistep Synthesis, day 2 | (nothing) | No | The project proposal and materials request for the Multistep Synthesis Project are due. |
| Thu Oct 8 | Exp. 38: Aromatic Multistep Synthesis, day 3 | (nothing) | No | |
| Tue Oct 13 | Exp. 39: Nucleophilic Aromatic Substitution | Prelab | Yes (SQ Answers) | You will need the Handbook supplement on Microwave-Assisted Chemistry. During this experiment, you will prepare the reaction for Synthesis of Frambinone. |
| Thu Oct 15 | Exp. 40: Coumarin Dyes | Prelab | Yes (SQ Answers) | |
| Tue Oct 20 | Exp. 41: Synthesis of Frambinone, day 1 | Prelab | Yes (SQ Answers) | Rheosmin paper cited for first step |
| Thu Oct 22 | Exp. 41: Synthesis of Frambinone, day 2 | (nothing) | No | |
| Tue Oct 27 | Exp. 42: Multistep Synthesis Project, day 1 | Prelab | No | |
| Thu Oct 29 | Exp. 42: Multistep Synthesis Project, day 2 | (nothing) | No | |
| Tue Nov 3 | Exp. 42: Multistep Synthesis Project, day 3 | (nothing) | No | |
| Thu Nov 5 | Exp. 42: Multistep Synthesis Project, day 4 | (nothing) | No | |
| Tue Nov 10 | Exp. 42: Multistep Synthesis Project, day 5 | (nothing) | No | |
| Thu Nov 12 | Exp. 42: Multistep Synthesis Project, day 6 | (nothing) | No | |
| Tue Nov 17 | Exp. 40: Multistep Synthesis Project Presentations, day 1 | (nothing) | No | |
| Thu Nov 19 | Exp. 40: Multistep Synthesis Project Presentations, day 2, & Lab Check-out | (nothing) | No | |
| Tue Dec 1 | Comprehensive Lab Quiz in Canvas | (nothing) | Yes | For the final quiz, you should review the study questions and prelab quizzes. |