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CHEM 3321: Laboratory for Organic Chemistry I

This lab course is for biochemistry and non-chemistry majors. A large part of Chem 3321 is spent learning techniques in organic chemistry, including TLC, distillation, extraction, crystallization, and IR spectroscopy. Once these techniques are mastered, they are employed in the final four labs of the semester. Two laboratory periods are devoted to working with molecular models sets to study nomenclature, conformational analysis, and stereochemistry.

TA office hours and emails are posted here.

101T10:20 AM-1:10 PMEKLC M1B20 
102T10:20 AM-1:10 PMEKLC M1B65 
111T1:50 PM-4:40 PMEKLC M1B20 
112T1:50 PM-4:40 PMEKLC M1B65 
121W10:20 AM-1:10 PMEKLC M1B20 
122W10:20 AM-1:10 PMEKLC M1B65 
123W10:20 AM-1:10 PMremote 
131W1:50 PM-4:40 PMEKLC M1B20 
132W1:50 PM-4:40 PMEKLC M1B65 
133W1:50 PM-4:40 PMremote 
141W5:30 PM-8:20 PMEKLC M1B20 
142W5:30 PM-8:20 PMEKLC M1B65 
143W5:30 PM-8:20 PMremote 
151R10:20 AM-1:10 PMEKLC M1B20 
152R10:20 AM-1:10 PMEKLC M1B65 
161R1:50 PM-4:40 PMEKLC M1B20 
162R1:50 PM-4:40 PMEKLC M1B65 
171R5:30 PM-8:20 PMEKLC M1B20 
172R5:30 PM-8:20 PMEKLC M1B65 
173R5:30 PM-8:20 PMremote 
181F10:20 AM-1:10 PMEKLC M1B20 
182F10:20 AM-1:10 PMEKLC M1B65 
191F1:50 PM-4:40 PMEKLC M1B20 
192F1:50 PM-4:40 PMEKLC M1B65 
194M10:20 AM-1:10 PMEKLC M1B20 
195M10:20 AM-1:10 PMEKLC M1B65 
196M1:50 PM-4:40 PMremote 
197M1:50 PM-4:40 PMremote 
198M5:30 PM-8:20 PMremote 
199M5:30 PM-8:20 PMremote

Experiment Schedule

Due to COVID, each lab section will be split into two groups, and only one group will perform an in-person experiment each week while the other group performs a remote experiment.

Dates for Group 1 Dates for Group 2 Experiment Quiz Notes
Aug 24 - Aug 28 Aug 31 - Sep 4 IN PERSON
Lab Check-in & Exp. 1: Lab Safety & IR Spectroscopy
No Be sure to read the safety chapter in the handbook before lab and wear proper lab attire. Experiment 1 and the Handbook chapters on Lab Safety and IR are available as PDFs in Canvas. This Lab Safety Movie and IR Tutorial may also help.
Aug 31 - Sep 4 Sep 7 - Sep 11 REMOTE
Exp. 2: NMR Spectroscopy
Yes (safety quiz) Chapter 18 & Chapter 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet (in the experiment manual) is due before you leave today. The Spectroscopy Homework is due later. Download this file and print the pages you are assigned.
Sep 7 - Sep 11 Sep 14 - Sep 18 IN PERSON
Exp. 3: Modeling Conformations, ChemDraw & Excel
Yes (NMR quiz) You can check out a model set if you don't have one. You can also save time by downloading and installing ChemDraw ahead of time.
Since Sep. 7 is Labor Day, Group 1 students in Monday labs will have to perform this experiment remotely.
Sep 14 - Sep 18 Sep 21 - Sep 25 REMOTE
Exp. 4: Labster I
No You will perform some virtual experiments in Labster this week. Details TBD.
Sep 21 - Sep 25 Sep 28 - Oct 2 IN PERSON
Exp. 5: Thin Layer Chromatography and Melting Point
Yes (SQ Answers) This is the first experiment this term that has a full lab report associated with it. The Handbook contains a chapter on writing lab reports. Be sure to write up a prelab and submit it in Canvas by the start of lab! TLC procedure and more
Melting points
Melting point movie (10:45 into the Crystallization movie)
During this experiment, you will also submit samples for your Practical NMR lab, so you can work up the spectra next week.
Sep 28 - Oct 2 Oct 5 - Oct 9 REMOTE
Exp. 6: Practical NMR
No You will need to download and install MestreNova, and get the NMR data files for this lab.
Oct 5 - Oct 9 Oct 12 - Oct 16 IN PERSON
Exp. 7: Extraction
Yes (SQ Answers) Extraction procedure
Extraction movie
Remember to save the product from this lab for the next lab.
Oct 12 - Oct 16 Oct 19 - Oct 23 REMOTE
Exp. 8: Labster II
No You will perform some virtual experiments in Labster this week. Details TBD.
Oct 19 - Oct 23 Oct 26 - Oct 30 IN PERSON
Exp. 9: Recrystallization
Yes (SQ Answers) Recrystallization movie
Recrystallization procedure
Oct 26 - Oct 30 Nov 2 - Nov 6 REMOTE
Exp. 10: Modelling Chirality & Cycloalkanes
No You can check out a model set if you don't have one.
Nov 2 - Nov 6 Nov 9 - Nov 13 IN PERSON
Exp. 11: Stereochemistry of Alkene Additions & Lab Check-out
No Instead of a prelab quiz, fill in the worksheet included with the lab.
If you have the 11th edition of the handbook, you will need the Handbook supplement on Green Chemistry.
Nov 9 - Nov 13 Nov 16 - Nov 20 REMOTE
Exp. 12: Labster III
No You will perform some virtual experiments in Labster this week. Details TBD.
Nov 16 - Nov 20 Nov 30 - Dec 4 REMOTE
Exp. 13: Labster IV
No You will perform some virtual experiments in Labster this week. Details TBD.
Nov 30 - Dec 4 Nov 30 - Dec 4 REMOTE
Final Quiz
Yes For the final quiz, you should review the study questions, worksheets and prelab quizzes.