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CHEM 3321: Laboratory for Organic Chemistry I

This lab course is for biochemistry and non-chemistry majors. A large part of Chem 3321 is spent learning techniques in organic chemistry, including TLC, distillation, extraction, crystallization, and IR spectroscopy. Once these techniques are mastered, they are employed in the final four labs of the semester. Two laboratory periods are devoted to working with molecular models sets to study nomenclature, conformational analysis, and stereochemistry.

TA office hours and emails are posted here.

101T10:00 AM-12:50 PMEKLC M1B65Madeline Walden
111T1:30 PM-4:20 PMEKLC M1B65John Flood
121W10:00 AM-12:50 PMEKLC M1B65Shea O'Sullivan
122W10:00 AM-12:50 PMEKLC M1B35Lacey Wayment
131W1:30 PM-4:20 PMEKLC M1B65John Flood
132W1:30 PM-4:20 PMEKLC M1B35Madeline Walden
151R10:00 AM-12:50 PMEKLC M1B65Tessa Myren
161R1:30 PM-4:20 PMEKLC M1B65Madeline Walden
181F10:00 AM-12:50 PMEKLC M1B65Tessa Myren
182F10:00 AM-12:50 PMEKLC M1B35Shea O'Sullivan
191F1:30 PM-4:20 PMEKLC M1B65Garrett Evenson

Experiment Schedule

Dates Experiment Bring Quiz Notes
Tue Jan 14 - Fri Jan 17 Lab Check-in & Exp. 1: Lab Safety & IR Spectroscopy Experiment Manual, lab attire Yes Be sure to read the safety chapter in the handbook before lab. In case you haven't purchased the lab books yet, Experiment 1 and the Handbook chapters on Lab Safety and IR are available as PDFs. This Lab Safety Movie may also help.
IR Tutorial
Tue Jan 21 - Fri Jan 24 Exp. 2: NMR Spectroscopy (nothing) No Chapter 18 & Chapter 20 in the Lab Handbook and Chapter 13 in Loudon; Spectroscopy Tutorial and NMR Theory Tutorial on this web site.
The in-class Spectroscopy Worksheet (in the experiment manual) is due before you leave today. The Spectroscopy Homework is due later. Download this file and print the pages you are assigned.
Tue Jan 28 - Fri Jan 31 Exp. 3: Modeling Conformations, ChemDraw & Excel Completed Spectroscopy Homework, modeling kit & laptop if you have one Yes (NMR quiz) You can check out a model set if you don't have one. You can also save time by downloading and installing ChemDraw ahead of time.
Tue Feb 4 - Fri Feb 7 Exp. 4: Practical NMR Laptop if you have one No You will need to download and install MestreNova, and get the NMR data files for this lab.
Tue Feb 11 - Fri Feb 14 Exp. 5: Thin Layer Chromatography and Melting Point Prelab Yes (SQ Answers) This is the first experiment this term that has a full lab report associated with it. Be sure to print a copy of the lab report rubric and attach it to your lab report when you turn it in at the next lab session.
TLC procedure and more
Melting points
Melting point movie (10:45 into the Crystallization movie)
Tue Feb 18 - Fri Feb 21 Exp. 6: Extraction Prelab Yes (SQ Answers) Extraction procedure
Extraction movie
Remember to save the product from this lab for the next lab.
Tue Feb 25 - Fri Feb 28 Exp. 7: Recrystallization Prelab Yes (SQ Answers) Recrystallization movie
Recrystallization procedure
Tue Mar 3 - Fri Mar 6 Exp. 8: Distillation Prelab Yes (SQ Answers) Distillation procedure GC Movie
Tue Mar 10 - Fri Mar 13 Exp. 9: Isolation of Limonene Prelab Yes (SQ Answers) If you have the 11th edition of the handbook, you will need the Handbook supplements on Green Chemistry and Optical Activity and Polarimetry.
Tue Mar 17 - Fri Mar 20 Exp. 10: Modelling Chirality & Cycloalkanes No You can check out a model set if you don't have one.
Tue Mar 24 - Fri Mar 27 No labs
Tue Mar 31 - Fri Apr 3 Exp. 11: Stereochemistry of Alkene Additions Prelab and worksheet No Instead of a prelab quiz, fill in the worksheet included with the lab.
If you have the 11th edition of the handbook, you will need the Handbook supplement on Green Chemistry.
Tue Apr 7 - Fri Apr 10 Exp. 12: Regiochemistry of Eliminations Prelab Yes (SQ Answers) You can download the NMR spectrum for 3-methylcyclohexene.
Tue Apr 14 - Fri Apr 17 Exp. 13: Oxidation of Alcohols Prelab Yes (SQ Answers)
Tue Apr 21 - Fri Apr 24 Lab Check-out & Final Quiz Yes For the final quiz, you should review the study questions, worksheets and prelab quizzes.